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Identification of Prostaglandin E2 as the Principal Vasodepressor Lipid of Rabbit Renal Medulla

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Abstract

INVESTIGATORS in several laboratories have reported on the isolation of vasoactive lipids from renal medulla of several species1–7. Muirhead et al.1 have separated these lipids into two classes: the antihypertensive lipids which prevent canine renoprival hypertension2 and lower canine renal hypertension3; and the more acidic vasodepressor lipids which acutely lower the blood pressure of the anaesthetized, vagotomized dog or rat treated with pentolinium4.

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References

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Authors and Affiliations

  1. Biochemistry Research, The Upjohn Company, Kalamazoo, Michigan

    E. G. DANIELS & J. W. HINMAN

  2. Department of Pathology, University of Tennessee, College of Medicine, Memphis, Tennessee

    B. E. LEACH & E. E. MUIRHEAD

  3. Baptist Memorial Hospital, Memphis, Tennessee

    B. E. LEACH & E. E. MUIRHEAD

Authors
  1. E. G. DANIELS
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  2. J. W. HINMAN
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  3. B. E. LEACH
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  4. E. E. MUIRHEAD
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DANIELS, E., HINMAN, J., LEACH, B. et al. Identification of Prostaglandin E2 as the Principal Vasodepressor Lipid of Rabbit Renal Medulla. Nature 215, 1298–1299 (1967). https://doi.org/10.1038/2151298a0

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