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Effects of Oestrone-17β-thiol on the Endocrine Organs of the Castrated Female Rat

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Abstract

THE biological properties of oestrone-17β-thiol (3-hydroxy 1,3,5 (10) oestratriene-17β-thiol) were compared with those of oestradiol-17β. Oestrone-17β-thiol has already been synthesized1–3, but no report of its biological properties has been published. We have investigated the effect of this compound on the weight of the endocrine organs, vaginal smear, and on adenohypophyseal histology in the castrated female rat. Adult animals were ovariectomized 15 days before the start of the experiments. Details of the investigation are given in Table 1a and b. All doses were compared with the same amounts of oestradiol-17β.

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References

  1. U.S. Patent 2,840,577 (1958).

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Author notes

  1. A. B. FAJER

    Present address: Department of Physiology, University of Maryland School of Medicine, Baltimore, 1, Maryland

Authors and Affiliations

  1. Laboratory of Experimental Endocrinology, and Zimotecnic Institute, University of São Paulo, Brazil

    A. B. FAJER, P. A. BOBBIO & HIROKO FURUYA

Authors
  1. A. B. FAJER
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  2. P. A. BOBBIO
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  3. HIROKO FURUYA
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FAJER, A., BOBBIO, P. & FURUYA, H. Effects of Oestrone-17β-thiol on the Endocrine Organs of the Castrated Female Rat. Nature 213, 401–402 (1967). https://doi.org/10.1038/213401a0

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