Abstract
Euploid human fibroblasts and amnion cells showed contact inhibition of growth in monolayers. In mixed cultures the two cell types did not inhibit each other. Neither inhibited the growth of aneuploid epithelial cells. What is the significance of these phenomena with regard to the growth of malignant tumours ?
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abercrombie, M. M., Heaysman, J. E. M., and Karthauser, H. M., Exp. Cell Res., 13, 276 (1957).
Abercrombie, M., and Heaysman, E. M., Exp. Cell Res., 6, 293 (1954).
Abercrombie, M., and Ambrose, E. J., Cancer Res., 22, 525 (1962).
Levine, E. M., Becker, Y., Boone, C. W., and Eagle, H., Proc. U.S. Nat. Acad. Sci., 53, 350 (1965).
Eagle, H., Washington, C., and Friedman, S. M., Proc. U.S. Nat. Acad. Sci., 56, 126 (1966).
Eagle, H., Science, 130, 432 (1959).
Oyama, V. I., and Eagle, H., Proc. Soc. Exp. Biol. and Med., 91, 305 (1956).
Barski, G., and Béléhradek, jun., J., Exp. Cell Res., 37, 464 (1965).
Stoker, M., Virology, 24, 165 (1964).
Stoker, M. G. P., Shearer, M., and O'Neill, C., J. Cell Sci., 1, 297 (1966).
Moscona, A. A., J. Cell. Comp. Physiol., 60, suppl. 1, 65 (1962).
Moscona, A. A., Eighteenth Symposium, Society for the Study of Development and Growth, 45 (Ronald Press Co., New York, 1960).
Weiss, P., Fifth Canadian Cancer Conference, 5, 241 (1963).
Grover, J. W., Dev. Biol., 3, 555 (1961).
Steinberg, M. S., Proc. U.S. Nat. Acad. Sci., 48, 1577 (1962).
Trinkaus, J. P., and Lentz, J. P., Dev. Biol., 9, 115 (1964).
Vogt, M., and Dulbecco, R., Proc. U.S. Nat. Acad. Sci., 46, 356 (1960).
Coman, D. R., Cancer Res., 4, 625 (1944).
Coman, D. R., Cancer Res., 13, 397 (1953).
Halpern, B., Pejsachowicz, B., Febvre, H. L., and Barski, G., Nature, 209, 157 (1966).
Pejsachowicz, B., Halpern, B., Febvre, H., and Barski, G., C.R. Acad. Sci., Paris, 259, 4891 (1964).
Foley, G. E., and Handler, A. H., Proc. Soc. Exp. Biol. and Med., 94, 661 (1957).
Foley, G. E., and Handler, A. H., Ann. N.Y. Acad. Sci., 76, 506 (1958).
Foley, G. E., Handler, A. H., Adams, R. A., and Craig, J. M., Nat. Cancer Inst. Monograph, 7, Symposium: Analytical Cell Culture, 11, 173 (1962).
Todaro, G. J., and Green, H., J. Cell Biol., 17, 299 (1963).
Defendi, V., Lehman, J., and Kraemer, P., Virology, 19, 592 (1963).
Todaro, G. J., Lazar, G. K., and Green, H., J. Cell. Comp. Physiol., 66, 325 (1966).
Kruse, P., and Miedema, E., J. Cell Biol., 27, 273 (1965).
Boveri, T., Verhandl. Physikol-med. Gesellschaft Wiirzburg., 35, 67 (1902). Reprinted in Foundations of Exp. Embryol. (edit. by Willier, B. H., and Oppenheimer, J. M.) (Prentice-Hall, Englewood Cliffs, N.J., 1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
EAGLE, H., LEVINE, E. Growth Regulatory Effects of Cellular Interaction. Nature 213, 1102–1106 (1967). https://doi.org/10.1038/2131102a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/2131102a0
- Springer Nature Limited
This article is cited by
-
Reciprocal regulation of cellular mechanics and metabolism
Nature Metabolism (2021)
-
Close Encounters of the Cell Kind: The Impact of Contact Inhibition on Tumour Growth and Cancer Models
Bulletin of Mathematical Biology (2020)
-
DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis
Oncogene (2019)
-
Cell–cell contacts protect against t-BuOOH-induced cellular damage and ferroptosis in vitro
Archives of Toxicology (2019)
-
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
Nature Communications (2018)