Abstract
DURING an, investigation of sporozoite induced, infections of Plasmodium berghei yoelii in mice, chloroquine was given in an attempt to eliminate the erythrocytic stages of the parasite. Unexpectedly, the parasite failed to respond to the drug.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Landau, I., and Killick-Kendrick, R., Trans. Roy. Soc. Trop. Med. Hyg., 60 (5), 633 (1966).
Hawking, F., Amer. J. Trop. Med. Hyg., 15, 287 (1966).
Landau, I., and Chabaud, A. G., C. R. Acad. Sci., Paris, 261, 230 (1965).
Yoeli, M., and Most, H., Amer. J. Trop. Med. Hyg., 14, 700 (1965).
Warhurst, D. C., Trans. Roy. Soc. Trop. Med. Hyg., 60 (1), 6 (1966).
Peters, W., Exp. Parasitol., 17 (1), 80 (1965).
Resistance of malaria parasites to drugs, Tech. Rep. Ser WHO, 296 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WARHURST, D., KILLICK-KENDRICK, R. Spontaneous Resistance to Chloroquine in a Strain of Rodent Malaria (Plasmodium berghei yoelii). Nature 213, 1048–1049 (1967). https://doi.org/10.1038/2131048a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2131048a0
- Springer Nature Limited
This article is cited by
-
Validation of a chloroquine-induced cell death mechanism for clinical use against malaria
Cell Death & Disease (2014)
-
Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria
BMC Genomics (2012)
-
Genetics of chloroquine resistance in malaria parasites
Nature (1976)
-
Effect of PABA on Chloroquine Resistance in Plasmodium berghei yoelii
Nature (1972)
-
Infectivity of Chloroquine Resistant Plasmodium berghei to Anopheles stephensi enhanced by Chloroquine
Nature (1969)