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Persistent Latent Infection of Human Embryonic Cells with Reovirus Type 3

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Abstract

ALTHOUGH latent infections with members of most of the virus groups occur regularly in man and animals, persistent latent infections of tissue cultures are less frequent. Electron microscopy has demonstrated such infections in cultures of baby hamster kidney1 and Burkitt's lymphoma cells2,3. Persistent latent infections of tissue cultures with adenoviruses4, mumps5, parainfluenza6, rabies7 and polyoma8,9 viruses have been produced artificially. The conditions necessary for prolonged culture are different for different viruses. Mitosis has been demonstrated in cells infected with Rous sarcoma10, influenza, Newcastle disease11, measles12 and reoviruses13. With FL cells infected with reoviruses, viral antigen is localized in the areas occupied by the spindles and centrioles.

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Author notes

  1. T. M. BELL: Leverhulme Trust Research Fellow.

  2. M. G. R. ROSS: Leverhulme Trust Research Assistant.

Authors and Affiliations

  1. Imperial Cancer Research Fund, P.O. Box 193, Entebbe, Uganda

    T. M. BELL & M. G. R. ROSS

Authors
  1. T. M. BELL
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  2. M. G. R. ROSS
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BELL, T., ROSS, M. Persistent Latent Infection of Human Embryonic Cells with Reovirus Type 3. Nature 212, 412–414 (1966). https://doi.org/10.1038/212412a0

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