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Experimental Infections of Cattle with Fasciola hepatica. Challenge Infections

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Abstract

PREVIOUS investigations1,2 in cattle have shown that with high level single infections of 2,500 to 15,000 metacercariae, a severe parenchymal reaction develops around the immature flukes. This inhibits the development of the migrating parasites and very few develop to adult flukes in the bile ducts. A similar situation has not been observed in other hosts. Attempts to produce an acquired immunity to Fasciola hepatica in sheep and laboratory animals have met with little success3. It is, however, possible that the inhibition recorded in single high level infections can operate in challenge infections and that cattle may differ from other hosts in their reaction to challenge.

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References

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Authors and Affiliations

  1. Veterinary Research Division, The Farm, Stormont, Belfast, 4

    J. G. Ross

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  1. J. G. Ross
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Ross, J. Experimental Infections of Cattle with Fasciola hepatica. Challenge Infections. Nature 212, 1464–1465 (1966). https://doi.org/10.1038/2121464a0

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