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Effect of Thorazine (Chlorpromazine) on Collagen Metabolism

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Abstract

IN the course of an investigation of the effect of partial body X-irradiation on collagen metabolism we used thorazine (chlorpromazine) as an aid in immobilizing rats1. We found quite unexpectedly that the incorporation of carbon-14-labelled amino-acids into collagen was markedly suppressed during the first month, and considerably enhanced 2–4 months after the injection of the drugs. The effect of thorazine on collagen metabolism was observed in all tissues, but was most pronounced in bone collagen. Because of the involvement of bone collagen, we feel that our findings should be brought to the attention of clinicians who may be treating fracture cases with, among other drugs, thorazine, a drug which may impair the healing process.

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References

  1. Traelnes, K. R., Ernst, H., Altman, K. I., and Hempelmann, L. H. (to be published).

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Authors and Affiliations

  1. Department of Experimental Radiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York

    H. ERNST, K. R. TRAELNES, K. I. ALTMAN & L. H. HEMPELMANN

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  1. H. ERNST
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  2. K. R. TRAELNES
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  3. K. I. ALTMAN
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  4. L. H. HEMPELMANN
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ERNST, H., TRAELNES, K., ALTMAN, K. et al. Effect of Thorazine (Chlorpromazine) on Collagen Metabolism. Nature 211, 880–881 (1966). https://doi.org/10.1038/211880a0

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