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Endotoxin-enhanced Host Resistance: Reversal by Kinetin Riboside

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Abstract

KINETIN riboside (6-furfurylaminopurine riboside) reverses the stimulatory effects of oligodeoxyribonucleotides on antibody synthesis1 and phagocytosis2. Evidence exists suggesting that some of the effects of bacterial endotoxins on increased host-resistance to pathogens may be associated with a release of such oligomers3, and it was considered of interest to determine the influence of kinetin riboside on the protective effects of endotoxin.

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References

  1. Braun, W., and Nakano, M., Proc. Soc. Exp. Biol. and Med., 119, 701 (1965).

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  2. Freedman, H., and Braun, W., Proc. Soc. Exp. Biol. and Med., 120, 222 (1965).

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  3. Braun, W., and Kessel, R. W. I., in Bacterial Endotoxins, edit. by Landy, M., and Braun, W., 397 (Rutgers University Press, 1964).

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Author notes

  1. R. W. I. KESSEL

    Present address: Department of Microbiology, University of Massachusetts, Amherst, Massachusetts

Authors and Affiliations

  1. Institute of Microbiology, Rutgers, The State University, New Brunswick, New Jersey

    R. W. I. KESSEL & WERNER BRAUN

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  1. R. W. I. KESSEL
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  2. WERNER BRAUN
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KESSEL, R., BRAUN, W. Endotoxin-enhanced Host Resistance: Reversal by Kinetin Riboside. Nature 211, 1001–1002 (1966). https://doi.org/10.1038/2111001a0

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