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Stabilization of Factor VIII by Glycerol

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Abstract

THE lability of the blood coagulation substance, factor VIII (antihaemophilic globulin, AHG, AHF), has hindered its investigation and has thus led to a search for techniques to stabilize it. Additions of glycerol1,2, gelatine3,4, human serum4, and human serum albumin4 were all found to stabilize factor VIII activity, but the degree of effectiveness of such additions has not been denned. The investigation reported here was an attempt to evaluate the action of glycerol in quantitative terms.

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References

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Author notes

  1. MEHRAN GOULIAN

    Present address: Department of Biochemistry, Stanford University School of Medicine, Stanford Medical Center, Palo Alto, California

Authors and Affiliations

  1. Department of Medicine, Harvard Medical School and the Hematology Research Laboratory of the Medical Service, Massachusetts General Hospital, Boston, Massachusetts

    MEHRAN GOULIAN & WILLIAM S. BECK

Authors
  1. MEHRAN GOULIAN
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  2. WILLIAM S. BECK
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GOULIAN, M., BECK, W. Stabilization of Factor VIII by Glycerol. Nature 211, 74–75 (1966). https://doi.org/10.1038/211074a0

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