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Selective Uptake of an Antibilharzial Nitrothiazole Compound by Schistosoma mansoni

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Abstract

REPORTS on the uptake of schistomicidal drugs in the parasite are few and so far have been limited to 124Sb-labelled antimonials1,2. Following the description of a potent nitrothiazole schistosomicide, 1-(5-nitro-2-thiazolyl)-2-imidazolidinone (Ciba 32,644-Ba)3,4, the distribution of this compound was studied in mice infected with Schistosoma mansoni. The 14C-labelled nitrothiazole was found to be highly concentrated in both adult worms and embryonated eggs.

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References

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Authors and Affiliations

  1. Research Laboratories, Pharmaceutical Department, Ciba, Ltd., Basle, Switzerland

    R. HESS, J. W. FAIGLE & C. LAMBERT

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  1. R. HESS
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  2. J. W. FAIGLE
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  3. C. LAMBERT
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HESS, R., FAIGLE, J. & LAMBERT, C. Selective Uptake of an Antibilharzial Nitrothiazole Compound by Schistosoma mansoni. Nature 210, 964–965 (1966). https://doi.org/10.1038/210964a0

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