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Carcinogenic Action of N-Methyl-N′-nitro-N-nitrosoguanidine

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Abstract

N-Methyl-N′-nitro-N-nitrosoguanidine (NG) is known to be a potent mutagenic substance for Escherichia coli1, Salmonella typhimurium2, and Chlamydomonas reinhardi3. Induction of chromosomal aberrations in the cells of root meristems of Vicia faba by NG has been reported4. It is claimed that NG is the most potent mutagen yet discovered, since NG induced at least one mutation per cell of Escherichia coli treated at the optimal condition permitting 50 per cent survival5. The production of a number of multi-site mutants resulting from the accumulation of single-site mutations has been noticed2,5.

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References

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Authors and Affiliations

  1. Biochemistry Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo

    TAKASHI SUGIMURA, MINAKO NAGAO & YOSHIKIYO OKADA

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  1. TAKASHI SUGIMURA
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  2. MINAKO NAGAO
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  3. YOSHIKIYO OKADA
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SUGIMURA, T., NAGAO, M. & OKADA, Y. Carcinogenic Action of N-Methyl-N′-nitro-N-nitrosoguanidine. Nature 210, 962–963 (1966). https://doi.org/10.1038/210962b0

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