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Labelled Depolarizing Drugs in Normal and Denervated Muscle

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Abstract

THE antagonism between d-tubocurarine and depolarizing relaxant drugs has been investigated by means of a decamethonium derivative labelled with radioactive iodine, the uptake of which in muscle is reduced in the presence of the antagonist1,2. The present investigations have shown that d-tubocurarine also reduces the uptake of decamethonium and of carbachol which have been labelled with tritium, and, in addition, the muscles have been sectioned so that a localized concentration of drug in the region of the nerve endings could be demonstrated.

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Authors and Affiliations

  1. Department of Pharmacology and Brain Research Institute, University of California Center for Health Sciences, Los Angeles

    D. B. TAYLOR, R. CREESE, O. A. NEDERGAARD & R. CASE

Authors
  1. D. B. TAYLOR
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  2. R. CREESE
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  3. O. A. NEDERGAARD
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  4. R. CASE
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TAYLOR, D., CREESE, R., NEDERGAARD, O. et al. Labelled Depolarizing Drugs in Normal and Denervated Muscle. Nature 208, 901–902 (1965). https://doi.org/10.1038/208901a0

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