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Ultrastructure of the Antigen-retaining Reticulum of Lymph Node Follicles as shown by High-resolution Autoradiography

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Abstract

PREVIOUS investigations in this laboratory1–4 have described the localization of antigens in lymphoid follicles. Much circumstantial evidence was presented for the existence in follicles of a highly specialized fine dendritic web of macrophage fibrils responsible for antigen trapping and retention. Light microscopy alone, however, proved inadequate for the unequivocal demonstration of the structure of this web. The electron microscopic investigation reported here has defined more precisely the sites of localization of Salmonella flagellar antigen in the rat popliteal lymph node.

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Authors and Affiliations

  1. Walter and Eliza Hall Institute, Melbourne, Australia

    JUDITH MITCHELL & A. ABBOT

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  1. JUDITH MITCHELL
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  2. A. ABBOT
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MITCHELL, J., ABBOT, A. Ultrastructure of the Antigen-retaining Reticulum of Lymph Node Follicles as shown by High-resolution Autoradiography. Nature 208, 500–502 (1965). https://doi.org/10.1038/208500b0

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