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Lethal Effects of Aggregation and Electric Shock in Mice treated with Cocaine

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Abstract

SENSORY stimuli provided by aggregation1 or sub-maximal electric shock2 become incompatible with life in mice treated with low doses of amphetamine. Effects of aggregation3,4 or electric shock5 on brain levels of norepinephrine are also modified by amphetamine. Amphetamine inhibits the uptake of norepinephrine by tissues in vitro6,7 and in vivo8. Termination of the biological actions of norepinephrine to a large extent depends on the tissue uptake or ‘recapturing’ of the free norepinephrine9. It is therefore postulated that toxicity of sensory stimuli in treated mice is partly due to the interference by amphetamine of the ‘recapturing’ of norepinephrine liberated from sympathetic nerves due to stimulation.

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Author notes

  1. HARBANS LAL

    Present address: University of Kansas School of Pharmacy, Lawrence, Kansas

Authors and Affiliations

  1. Psychiatry Service, Veterans Administration Research Hospital, Chicago, Illinois

    HARBANS LAL & RICHARD D. CHESSICK

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  1. HARBANS LAL
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  2. RICHARD D. CHESSICK
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LAL, H., CHESSICK, R. Lethal Effects of Aggregation and Electric Shock in Mice treated with Cocaine. Nature 208, 295–296 (1965). https://doi.org/10.1038/208295a0

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