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Lactic Dehydrogenase Isoenzymes in Muscle from Patients with Duchenne Muscular Dystrophy

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Abstract

THE enzyme lactic dehydrogenase (LDH) can be separated into five different isoenzymes, each composed of a tetramere of one or both of two distinct polypeptides1,2. Isoenzymes 1 and 5 are composed solely of one of these two polypeptides, and isoenzymes 2, 3 and 4 consist of combinations of the two polypeptides. Tho proportions of the five isoenzymes vary from tissue to tissue, during development and with certain other environmental factors3,4. In skeletal muscle one such factor is the amount of muscle activity4.

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Authors and Affiliations

  1. Department of Pediatrics and Department of Surgery, School of Medicine, University of Washington, Seattle

    THOMAS H. SHEPARD, LAWRENCE H. GORDON & JOHN E. WOLLENWEBER

Authors
  1. THOMAS H. SHEPARD
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  2. LAWRENCE H. GORDON
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  3. JOHN E. WOLLENWEBER
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SHEPARD, T., GORDON, L. & WOLLENWEBER, J. Lactic Dehydrogenase Isoenzymes in Muscle from Patients with Duchenne Muscular Dystrophy. Nature 208, 1107–1108 (1965). https://doi.org/10.1038/2081107a0

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