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Activity of Nicotine and Inactivity of Kallikrein and Kallidin in Aggregation of Blood Platelets

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Abstract

IN 1961, Gaarder et al.1 reported that adenosine diphos-phate (ADP) causes human blood platelets to aggregate. Born et al.2,3 described a method by which the aggregation of platelets may be followed quantitatively. They confirmed the results of Gaarder and described inhibition of the ADP-effect by 2-chloroadenosine and other substituted nucleosides4. Lately, some more results on this subject have been published5–7, but the mechanism of platelet aggregation is still unknown.

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Authors and Affiliations

  1. Klinisch-Chemisches Institut an der Chirurgischen Klinik der Universität München, Germany

    E. WERLE & H. SCHIEVELBEIN

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  1. E. WERLE
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  2. H. SCHIEVELBEIN
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WERLE, E., SCHIEVELBEIN, H. Activity of Nicotine and Inactivity of Kallikrein and Kallidin in Aggregation of Blood Platelets. Nature 207, 871–872 (1965). https://doi.org/10.1038/207871a0

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