References
Goldstein, A., Pharmacol. Rev., 1, 102 (1949).
Edsall, J. T., and Wyman, J., Biophysical Chemistry, 1 (Academic Press New York, 1958).
Stafford, W. L., in Salicylates, an International Symposium, edit. by Dixon, A. St. J., Martin, B. K., Smith, M. J. H., and Wood, P. H. N. (Churchill, London, 1963).
Thorp, J. M., in Absorption and Distribution of Drugs, edit. by Binns, T. B. (Livingstone, London, 1964).
Brodie, B. B., Absorption and Distribution of Drugs, edit. by Binns, T. B., 236 (Livingstone, London, 1964).
Anton, A. J., J. Pharm. Exp. Therap., a, 129, 282 (1960); b, 134, 291 (1961).
Van Os, G. A. J., in Molecular Pharmacology, 1, 29, edit. by Ariëns, E. J. (Academic Press, New York, 1964).
Burns, J. J., Rose, R. K., Chenkin, T., Goldman, A., Schulert, A., and Brodie, B. B., J. Pharm. Exp. Therap., 109, 346 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MARTIN, B. Potential Effect of the Plasma Proteins on Drug Distribution. Nature 207, 274–276 (1965). https://doi.org/10.1038/207274a0
Issue Date:
DOI: https://doi.org/10.1038/207274a0
- Springer Nature Limited
This article is cited by
-
The Male Genital Tract Is Not a Pharmacological Sanctuary From Efavirenz
Clinical Pharmacology & Therapeutics (2011)
-
Nonlinear protein binding and enzyme heterogeneity: Effects on hepatic drug removal
Journal of Pharmacokinetics and Biopharmaceutics (1993)
-
Generalized pharmacokinetic modeling for drugs with nonlinear binding: I. Theoretical framework
Journal of Pharmacokinetics and Biopharmaceutics (1993)
-
Binding of teicoplanin to human serum albumin
European Journal of Clinical Pharmacology (1987)
-
Melphalan concentration dependent plasma protein binding in healthy humans and rats
European Journal of Clinical Pharmacology (1987)