Skip to main content
Log in

Acetylcholinesterase in the Sarcoplasmic Reticulum of Skeletal Muscle

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

IN the region of the end-plate of skeletal muscle a high concentration of acetylcholinesterase (AChE) has been proved by histochemical1–8, as well as by biochemical9,10, methods. There is, however, still disagreement about the localization of the AChE in the ultrastructure of the synapse. Nachmansohn11 and Eccles12 consider the high AChE concentration a prerequisite to the functionally necessary, rapid inactivation of the chemical transmitter acetylcholine (ACh).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Zacks, S. I., and Blumberg, J. M., J. Histochem. Cytochem., 9, 317 (1961).

    Article  CAS  Google Scholar 

  2. Barrnett, R. J., and Palade, G. E., J. Biophys. Biochem. Cytol., 6, 163 (1959).

    Article  CAS  Google Scholar 

  3. Miledi, R., Nature, 204, 293 (1964).

    Article  ADS  CAS  Google Scholar 

  4. Lehrer, G. M., and Ornstein, L., J. Biophys. Biochem. Cytol., 6, 399 (1959).

    Article  CAS  Google Scholar 

  5. Brown, L. M., Bibl. Anat., 2, 21 (1961).

    Google Scholar 

  6. Barrnett, R. J., J. Cell Biol., 12, 247 (1962).

    Article  CAS  Google Scholar 

  7. Couteaux, R., Proc. Roy. Soc., B, 158, 457 (1963).

    Article  ADS  CAS  Google Scholar 

  8. Ulbrecht, M., Biochim. Biophys. Acta, 57, 438 (1962).

    Article  CAS  Google Scholar 

  9. Giacobini, E., and Holmstedt, B., Acta Pharmacol. Toxicol., 17, 94 (1960).

    Article  CAS  Google Scholar 

  10. Brzin, M., and Zeuthen, E., C.R. trav. lab. Carlsberg, 32, 159 (1961).

    Google Scholar 

  11. Nachmansohn, D., Chemical and Molecular Basis of Nerve Activity (Academic Press, New York, 1959).

    Google Scholar 

  12. Eccles, J. C., Physiology of Synapses (Springer, Berlin, 1964).

    Book  Google Scholar 

  13. Jacob, J., and Pecot-Dechavassine, M., Experientia, 14, 330 (1958).

    Article  CAS  Google Scholar 

  14. Ord, M. G., and Thompson, R. H. S., Biochem. J., 46, 546 (1950).

    Article  Google Scholar 

  15. Couteaux, R., and Nachmansohn, D., Proc. Soc. Exp. Biol. and Med., 43, 77 (1940).

    Article  Google Scholar 

  16. Karnovsky, M. J. (personal communication).

  17. Karnovsky, M. J., and Hug, K., J. Cell Biol., 19, 255 (1963).

    Article  CAS  Google Scholar 

  18. Varga, E., König, T., Kiss, E., Kovacs, T., and Hegedüs, L., Acta Physiol. Hung., 7, 171 (1955).

    CAS  Google Scholar 

  19. Kövér, A., and Kovács, T., Acta Physiol. Hung., 11, 260 (1957).

    Google Scholar 

  20. Kövér, A., Kovács, T., and König, T., Acta Physiol. Hung., 11, 253 (1957).

    PubMed  Google Scholar 

  21. Albers, H., Hoppe-Seylers Z. Physiol. Chem., 218, 113 (1933).

    Article  CAS  Google Scholar 

  22. Huxley, H. E., Nature, 202, 1067 (1964).

    Article  ADS  CAS  Google Scholar 

  23. Endo, M., Nature, 202, 1115 (1964).

    Article  ADS  CAS  Google Scholar 

  24. Couteaux, R., and Taxi, J., Arch. Anat. Micro. Morph. Exp., 41, 352 (1952).

    Google Scholar 

  25. Couteaux, R., Grundfest, H., Nachmansohn, D., and Rothenberg, M. A., Science, 104, 317 (1946).

    Article  ADS  CAS  Google Scholar 

  26. Rothenberg, M. A., Sprinson, D. B., and Nachmansohn, D., J. Neuro physiol., 11, 111 (1948).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ULBRECHT, G., KRUCKENBERG, P. Acetylcholinesterase in the Sarcoplasmic Reticulum of Skeletal Muscle. Nature 206, 305–306 (1965). https://doi.org/10.1038/206305a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/206305a0

  • Springer Nature Limited

This article is cited by

Navigation