Skip to main content
SpringerLink
Log in

Stress-induced Suppression of Interferon Production in Virus-infected Mice

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

INCREASED susceptibility to various viruses has been observed in mice exposed to psychological stress1, in which adrenal hyperactivity is considered to be a mediator. The decrease in resistance of stressed mice to vesicular stomatitis virus (VSV) appears not to be related to impairment of antibody response2. Interferon has been proposed as an important factor in recovery from viral infections3, and interferon production in the chick embryo is inhibited by exogenous corticoid4. For these reasons, the following experiments were performed to determine whether the levels of interferon produced in vivo differ between stressed and unstressed mice infected with viruses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rasmussen, jun., A. F., Marsh, J. T., and Brill, N. Q., Proc. Soc. Exp. Biol. and Med., 96, 183 (1957). Lavender, J. F., Johnsson, T., and Rasmussen, jun., A. F., Bact. Proc., 95 (1960). Jensen, M. M., and Rasmussen, jun., A. F., J. Immunol., 90, 21 (1963). Johnsson, T., Lavender, J. F., Hultin, B., and Rasmussen, jun., A. F., J. Immunol., 91, 569 (1963).

    Article  Google Scholar 

  2. Yamada, A., Jensen, M. M., and Rasmussen, jun., A. F., Proc. Soc. Exp. Biol. and Med. (in the press).

  3. Isaacs, A., and Lindenmann, J., Proc. Roy. Soc., B, 147, 258 (1957). Isaacs, A., Adv. Virus Res., 10, 1 (1963). Baron, S., Adv. Virus Res., 10, 39 (1963).

    Article  ADS  CAS  Google Scholar 

  4. Kilbourne, E. D., Smart, K. M., and Pokorny, B. A., Nature, 190, 650 (1961).

    Article  ADS  CAS  Google Scholar 

  5. Chang, S.-S., and Rasmussen, jun., A. F., Bact. Proc., 134 (1964).

Download references

Author information

Author notes

  1. SHUEH-SHEN CHANG: Post-doctoral Fellow of the U.S. National Academy of Sciences.

Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, School of Medicine, University of California, Los Angles

    SHUEH-SHEN CHANG & A. F. RASMUSSEN JUN.

Authors
  1. SHUEH-SHEN CHANG
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. F. RASMUSSEN JUN.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CHANG, SS., RASMUSSEN, A. Stress-induced Suppression of Interferon Production in Virus-infected Mice. Nature 205, 623–624 (1965). https://doi.org/10.1038/205623a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/205623a0

  • Springer Nature Limited

This article is cited by

Search

Navigation