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Hæmoglobin OArab in Bulgaria

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Abstract

SEVERAL cases of moderately severe hypochromic hæmolytic anæmia have recently been observed in Burgas, Bulgaria1. The affected individuals were unrelated white adult men and women. They showed splenomegaly, slight icterus, decreased osmotic fragility of the red cells and 40–90 per cent target cells. Paper and starch-gel electrophoresis2 at pH 8.6 of their hæmoglobin showed complete absence of normal adult hæmoglobin (Hb A) and presence of a slow-moving abnormal hæmoglobin. The electrophoretic mobility of this abnormal hæmoglobin was similar in paper electrophoresis to that of hæmoglobin C (Hb C). In starch-gel electrophoresis the abnormal hæmoglobin moves slightly ahead of Hb C. In agar-gel electrophoresis at pH 6.03 it moved between Hb A and Hb C, in the position of hæmoglobin S (Fig. 1).

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Authors and Affiliations

  1. State Hospital, Burgas, Bulgaria

    K. N. KANTCHEV & B. TCHOLAKOV

  2. International Laboratory of Genetics and Biophysics, Naples, Italy

    C. BAGLIONI & B. COLOMBO

Authors
  1. K. N. KANTCHEV
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  2. B. TCHOLAKOV
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  3. C. BAGLIONI
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  4. B. COLOMBO
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KANTCHEV, K., TCHOLAKOV, B., BAGLIONI, C. et al. Hæmoglobin OArab in Bulgaria. Nature 205, 187–188 (1965). https://doi.org/10.1038/205187a0

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