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Acid Secretion and Electrogenesis in Isolated Rat Stomach

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Abstract

THE physiological aspects of acid secretion have been investigated for many years in the dog1, while Teorell's work in the cat has provided much information on the relation to CO2 of various ions involved in secretion2. There have been extensive in vitro investigations of the transport mechanisms in frog tissue3, and it has been shown that electrical phenomena in these preparations are substantially dependent on chloride ions4,5. In contrast, more recent in-vitro experiments with rat tissue6 show that gastric bioelectric activity depends on sodium ion movement. Because it was possible to characterize a sodium-dependent mechanism in the rat by substitution and ionic flux determinations7, we decided to investigate the relation between acid secretion and the sodium-specific transmural potential. The evidence, described here, suggests that changes in potential and in acid secretion are essentially independent of each other.

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Authors and Affiliations

  1. Biological and Medical Sciences Division, U.S. Naval Radiological Defense Laboratory, San Francisco

    J. T. CUMMINS & B. E. VAUGHAN

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  1. J. T. CUMMINS
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  2. B. E. VAUGHAN
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CUMMINS, J., VAUGHAN, B. Acid Secretion and Electrogenesis in Isolated Rat Stomach. Nature 205, 1329–1330 (1965). https://doi.org/10.1038/2051329a0

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