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Application of Particle Electrophoresis to the Detection of Antibody bound to Cells of Streptococcus pyogenes

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Abstract

ALTHOUGH it has rarely been used for this purpose the microelectrophoretic technique1 is well suited for the detection of antibody adsorbed to bacterial cells. The antigen–antibody reactions between a single strain of Streptococcus pyogenes type 6 matt variant (N.C.T.C. 8302) and antisera for its type-specific M and T antigens, and for the group specific C antigen, have been investigated in this way. The type-specific sera were fully absorbed to remove heterologous cross-reactions. The group-specific sera were unabsorbed but showed no cross-reactions with other groups.

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References

  1. Gittens, G. J., and James, A. M., Anal. Biochem., 1, 478 (1960).

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  2. Hill, M. J., James, A. M., and Maxted, W. R., Biochim. Biophys. Acta, 66, 264 (1963).

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Authors and Affiliations

  1. Department of Chemistry, Chelsea College of Science and Technology, Manresa Road, London, S.W.3

    M. J. HILL & A. M. JAMES

  2. Streptococcal Reference Laboratory, Central Public Health Laboratory, Colindale, London, N.W.9

    W. R. MAXTED

Authors
  1. M. J. HILL
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  2. A. M. JAMES
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  3. W. R. MAXTED
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HILL, M., JAMES, A. & MAXTED, W. Application of Particle Electrophoresis to the Detection of Antibody bound to Cells of Streptococcus pyogenes. Nature 202, 187–188 (1964). https://doi.org/10.1038/202187a0

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