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Effect of an Erythropoietin Preparation on Uptake of Iron-59 by Tibiæ of New-born Rats

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Abstract

BOTH the site and mechanism of action of erythropoietin (ESF) remain to be elucidated. Some investigators have stated that ESF acts exclusively on the hæmocytoblast or stem cell, with the resulting production of increased numbers of erythrocytic cells1,2; others have presented evidence that ESF also may act on red blood cells that have advanced beyond the stem cell stage3–6. We have performed experiments to assess the ability of whole bones to incorporate radio-iron in vitro. Various ESF preparations extracted from rabbit plasma caused significant increases in iron-59 uptake in such bones; but similar effects were not observed with a more purified extract obtained from sheep plasma.

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Authors and Affiliations

  1. Departments of Medicine and Anatomy, Albert Einstein College of Medicine, New York, 61

    S. FISCHER & G. J. FRUHMAN

  2. Department of Virology, School of Medicine, University of Chile, Santiago

    S. FISCHER

Authors
  1. S. FISCHER
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  2. G. J. FRUHMAN
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FISCHER, S., FRUHMAN, G. Effect of an Erythropoietin Preparation on Uptake of Iron-59 by Tibiæ of New-born Rats. Nature 201, 836–838 (1964). https://doi.org/10.1038/201836a0

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