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Absence of Secondary Disease in Rats treated with Homologous Bone Marrow Transfusions after Administration of ‘Myleran’

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Abstract

IT has been shown in this laboratory that under some experimental conditions the homologous bone marrow treatment may be successful in preventing fatal bone marrow aplasia induced by high doses of ‘Myleran’1,2. On the other hand, it is well known that a number of lethally whole-body irradiated mammals, which survive the first 30 days after exposure, thanks to homologous or heterologous bone marrow transfusions, may succumb during the second and third month3,4. This delayed mortality known as secondary disease is attributed by several investigators to an immunological reaction of the graft versus the host. Some success has been reported in preventing or treating the secondary disease in irradiated animals by various means5–10. In this communication the preliminary results concerning absence of secondary disease in rats treated with homologous bone marrow transfusions after administration of ‘Myleran’ are given.

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  1. Department of Radiobiology, Cancer Institute, University of Louvain,

    A. DUNJIC

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  1. A. DUNJIC
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DUNJIC, A. Absence of Secondary Disease in Rats treated with Homologous Bone Marrow Transfusions after Administration of ‘Myleran’. Nature 198, 603–604 (1963). https://doi.org/10.1038/198603b0

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