5-Chloro-2-cyclohexyl-1-oxo-6-sulphamoyl Isoindoline : a New Diuretic

Abstract

THE introduction of chlorothiazide (Table 1, I) in 1957 marked a major advance¹ in the search for improved non-mercurial diuretics. Its advent was followed by a succession of more potent derivatives². Clinically, however, apart from the size of dose, all these derivatives produced a similar therapeutic response³. One of the few disadvantages of these compounds is the loss of potassium which occurs concurrently with the excretion of sodium ions and can necessitate the administration of potassium supplements.