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Rapid Inhibition by Cortisol of Incorporation of Glucose in vivo into the Thymus of the Rat

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Abstract

THE hypothesis that the effects of glucocorticoids on certain extrahepatic tissues result from inhibition of glucose utilization was proposed in 1942 by Drury1 and Ingle2 in connexion with the protein-catabolic effects of these hormones. It was later brought up by Bullough3 to explain mitotic inhibition in skin, and related phenomena such as involution of lymphatic tissue. Support for the hypothesis has recently come from several observations4–7, including demonstrations that glucocorticoids in vitro at concentrations approaching physiological levels inhibit glucose uptake by skin4 and adipose tissue5, and in vivo reduce glucose uptake by adipose tissue isolated 30 min after injection5. A number of arguments have been advanced for the view that this action represents the primary metabolic effect of the hormones on adipose tissue5.

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References

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Authors and Affiliations

  1. Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire

    DONALD BARTLETT, YOSHIKO MORITA & ALLAN MUNCK

Authors
  1. DONALD BARTLETT
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  2. YOSHIKO MORITA
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  3. ALLAN MUNCK
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BARTLETT, D., MORITA, Y. & MUNCK, A. Rapid Inhibition by Cortisol of Incorporation of Glucose in vivo into the Thymus of the Rat. Nature 196, 897–898 (1962). https://doi.org/10.1038/196897a0

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