Abstract
BOLLAG1 first reported that pregnant rats given an injection of ‘Busulphan’ 5–7 days before parturition produced sterile offspring. Later, Galton and Till2 stated that “earlier in pregnancy quite large doses do not interfere with its course and the F1 and F2 generations are apparently healthy”. In view of these studies and our knowledge of the effect of ‘Busulphan’ on the adult rat testis3–5, it was decided to reinvestigate the sensitivity of the proliferating cell systems of the fœtal gonad during development.
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References
Bollag, W., Schweiz. med. Wschr., 84, 393 (1954).
Galton, D. A. G., and Till, M., Adv. Cancer Res., 4, 83 (1956).
Craig, A. W., Fox, B. W., and Jackson, H., Nature, 181, 353 (1958).
Jackson, H., Fox, B. W., and Craig, A. W., Brit. J. Pharmacol., 14, 149 (1959).
Jackson, H., Fox, B. W., and Craig, A. W., J. Reprod. Fertil., 2, 447 (1961).
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HEMSWORTH, B., JACKSON, H. Effect of ‘Busulphan’ on the Fœtal Gonad. Nature 195, 816–817 (1962). https://doi.org/10.1038/195816a0
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DOI: https://doi.org/10.1038/195816a0
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