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Influence of Salicylate on Cortisol Secretion in the Dog

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Abstract

SIMILAR antiphlogistic and biochemical effects of salicylate, adrenocorticotropic hormone (ACTH) and cortisol1 have stimulated interest in establishing a possible influence of salicylate on the secretion of adrenocortical hormones in man and experimental animals. Studies in dogs, guinea pigs and rats have shown a stimulatory effect of salicylate on cortisol secretion2. It has been emphasized, however, that these experiments used a dose per unit of body-weight greater than the comparable therapeutic dose in man3,4. Furthermore, an anti-rheumatic effect of salicylate has been demonstrated in a patient whose adrenocortical function had been suppressed by 9-α-fluorohydrocortisone5. In view of this conflicting evidence, the present work was designed to determine whether or not salicylate has a direct stimulatory effect on the adrenal cortex.

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Author notes

  1. RICHARD S. CRAMPTON: Trainee of the New York Heart Association (1960–61).

  2. WILLIAM C. BLACK: Fellow of the New York Heart Association (1960–61).

  3. ARTHUR S. VERDESCA: Fellow of the U.S. National Institutes of Health (1960–61).

Authors and Affiliations

  1. Laboratory for Endocrine and Renal Physiology, Department of Medicine, St. Luke's Hospital, New York, 25

    RICHARD S. CRAMPTON, WILLIAM C. BLACK, ARTHUR S. VERDESCA, RELJA I. NEDELJKOVIC & JAMES G. HILTON

Authors
  1. RICHARD S. CRAMPTON
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  2. WILLIAM C. BLACK
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  3. ARTHUR S. VERDESCA
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  4. RELJA I. NEDELJKOVIC
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  5. JAMES G. HILTON
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CRAMPTON, R., BLACK, W., VERDESCA, A. et al. Influence of Salicylate on Cortisol Secretion in the Dog. Nature 194, 295–296 (1962). https://doi.org/10.1038/194295a0

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