Abstract
THE mouse has been used by several investigators for experimental work with Fasciola hepatica infections1–5. During the course of investigations described in this communication mice infected with 10 or 20 normal metacercariæ generally died 18–35 days after oral or intraperitoneal infection; most mice died 22–26 days after infection. At post-mortem examination immature flukes have been found in the body cavity, thoracic cavity and liver. Occasionally mature flukes have been found in the greatly enlarged bile duct 37 days after infection and a few mice have survived for at least 60 days with as many as 5 mature flukes in the bile duct.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Shirai, M., Sci. Rep. G. Inst. Infect. Dis. Tokyo Univ., 6, 511 (1927).
Taylor, E. L., and Parfitt, J. W., Trans. Amer. Micro. Soc., 76, 327 (1957).
Hughes, D. L., M.Sc. thesis, University of London (1959).
Dawes Ben, J. Helminth., R. T. Leiper Supp., 41 (1961).
Lagrange, E., and Gutmann, A., Rivista di Parasitologia, 22, N2, 93 (1961).
Villella, J. B., Gomberg, H. J., and Gould, S. E., Science, 134, 1073 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HUGHES, D. Reduction of the Pathogenicity of Fasciola hepatica in Mice by X-Irradiation. Nature 193, 1093–1094 (1962). https://doi.org/10.1038/1931093a0
Issue Date:
DOI: https://doi.org/10.1038/1931093a0
- Springer Nature Limited