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Antigenicity of Deoxyribonucleic Acids from Mouse Liver and from the Ehrlich Ascites Tumour

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Abstract

IN recent years, a number of reports have appeared concerning the antigenicity of mammalian and bacterial deoxyribonucleic acid. Evidence has been presented indicating that complement-fixing1 and precipitating2 antibodies may be produced by the injection of such preparations into experimental animals. In addition, serum from patients with systemic lupus erythematosus has been shown to react immunologically with highly purified deoxyribonucleic acid from a variety of sources3. The present communication concerns the production of antisera by the immunization of rabbits with deoxyribonucleic acid preparations isolated from mouse liver and from cells of the Ehrlich ascites tumour. The results obtained indicate that anti-tumour cell deoxyribonucleic acid serum has an inhibitory effect on the growth of the tumour in vivo.

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Author notes

  1. K. A. O. ELLEM: Travelling Fellow of the New South Wales State Cancer Council.

Authors and Affiliations

  1. The Wistar Institute, 36th Street at Spruce, Philadelphia, Penn.

    J. S. COLTER & K. A. O. ELLEM

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  1. J. S. COLTER
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  2. K. A. O. ELLEM
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COLTER, J., ELLEM, K. Antigenicity of Deoxyribonucleic Acids from Mouse Liver and from the Ehrlich Ascites Tumour. Nature 190, 550–551 (1961). https://doi.org/10.1038/190550b0

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