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Methods for Determining the Rates of Catalase Synthesis and Destruction in vivo

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Abstract

ALTERATIONS in the amount of enzyme in a tissue can result from changes in the rate of synthesis or of destruction. The demonstration that 3-amino-1,2,4-triazole irreversibly inactivates catalase in the liver1 without interfering with its resynthesis2, and allyl-isopropyl acetamide blocks synthesis of new catalase3 suggested that these compounds might be used as tools for studying the kinetics of catalase synthesis and destruction in vivo.

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Author notes

  1. M. RECHCIGL: Public Health Service Research Fellow.

Authors and Affiliations

  1. Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland

    V. E. PRICE, M. RECHCIGL JUN. & R. W. HARTLEY JUN.

Authors
  1. V. E. PRICE
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  2. M. RECHCIGL JUN.
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  3. R. W. HARTLEY JUN.
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PRICE, V., RECHCIGL, M. & HARTLEY, R. Methods for Determining the Rates of Catalase Synthesis and Destruction in vivo. Nature 189, 62–63 (1961). https://doi.org/10.1038/189062a0

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