Skip to main content
SpringerLink
Log in

Tolerance to Maternal Skin Grafts in Rabbits induced by Hyaluronidase

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

VASCULARIZED transplants are permanently successful only between identical twins or within a highly inbred strain. Even homografts from the mother to her litter are destroyed by the immunological process initiated by her transplant antigens1. However, tolerance for individual specific transplant antigens can be produced by the direct injection of donor cells into the fœtal or neo-natal animal1. These offspring accept grafts of normal tissue from the antigen donor. In contrast, uninjected control animals reject similar homologous transplants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Billingham, R. E., Brent, L., and Medawar, P. B., Phil. Trans. Roy. Soc., B, 239, 357 (1956).

    ADS  Google Scholar 

  2. Lengerova, A., Folia Biologica (Prague), 3, 333 (1957).

    Google Scholar 

  3. Porter, K. A., Nature, 185, 789 (1960).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. May Institute for Medical Research of the Jewish Hospital of Cincinnati,

    PAUL NATHAN, EDUARDO GONZALEZ & BENJAMIN F. MILLER

  2. the Departments of Physiology and Medicine, University of Cincinnati College of Medicine,

    PAUL NATHAN, EDUARDO GONZALEZ & BENJAMIN F. MILLER

Authors
  1. PAUL NATHAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. EDUARDO GONZALEZ
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. BENJAMIN F. MILLER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

NATHAN, P., GONZALEZ, E. & MILLER, B. Tolerance to Maternal Skin Grafts in Rabbits induced by Hyaluronidase. Nature 188, 77–78 (1960). https://doi.org/10.1038/188077a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/188077a0

  • Springer Nature Limited

This article is cited by

Search

Navigation