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Effect of a Primary Tuberculous Infection on the Resistance of Male and Female Mice to Ectromelia

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Abstract

A TUBERCULOUS infection or vaccination with BCG has been shown to raise the resistance of mice and guinea pigs not only to a challenge with mycobacteria but also to secondary infections caused by other species of bacteria. This latter, non-specific type of immunity has been demonstrated against infection with Brucella abortus 1, Bacillus anthracis and Brucella suis 5, Staphylococcus aureus 2, Pasteurella pestis 3 and Salmonella enteritidis 6. The present work was undertaken to see whether a primary tuberculous infection also increased the resistance of mice to virus infections, using in the first instance ectromelia (mouse pox) as the test virus.

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Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, N.W.7

    A. W. GLEDHILL & R. J. W. REES

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  1. A. W. GLEDHILL
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  2. R. J. W. REES
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GLEDHILL, A., REES, R. Effect of a Primary Tuberculous Infection on the Resistance of Male and Female Mice to Ectromelia. Nature 187, 703–704 (1960). https://doi.org/10.1038/187703b0

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