Skip to main content
SpringerLink
Log in

Structures of Some Acetyl-serine Peptides from Acetyl-chymotrypsin

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

IN 1958, two of us1 obtained, by enzymic degradation of acetyl-chymotrypsin labelled with carbon-142, five peptides containing labelled acetyl-groups. Subsequent sequence studies3 have shown that the largest of these peptides has the amino-acid sequence, Gly.Asp.Ser.Gly.Gly.Pro.Leu, identical with that already found4, by degradation of the di-isopropylphosphoryl-enzyme, to surround the reactive serine ; it may reasonably be concluded that the other four peptides contain the sequences Ser.Gly.Gly.Pro.Leu, Asp.Ser.Gly.Gly, Gly.Asp.Ser.Gly and Ser.Gly.Gly, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Oosterbaan, and van Adrichem, Biochim. Biophys. Acta, 27, 423 (1958).

    Article  CAS  Google Scholar 

  2. Balls, J. Biol. Chem., 219, 245 (1956).

    CAS  Google Scholar 

  3. Jansz, Berends, and Oosterbaan, Rec. Trav. Chim., 78, 876 (1959). Cohen, Oosterbaan, Jansz, and Berends, J. Cell. Comp. Physiol., 54, Supp. 1, 231 (1959).

    Article  CAS  Google Scholar 

  4. Oosterbaan, Jansz, and Cohen, Biochim. Biophys. Acta, 20, 402 (1956). Oosterbaan, Kunst, van Rotterdam, and Cohen, ibid., 27, 549, 556 (1958).

    Article  Google Scholar 

  5. Benoiton, and Rydon, J. Chem. Soc. (in the press).

  6. Porter, Rydon, and Schofield, Nature, 182, 927 (1958). Rydon, ibid., 182, 928 (1958).

    Article  ADS  CAS  Google Scholar 

  7. For references, see the review by Davies and Green, “Adv. Enzymol.”, 20, 283 (1958).

Download references

Author information

Authors and Affiliations

  1. Washington Singer Laboratories, The University, Exeter

    LEO BENOITON & H. N. RYDON

  2. Medical Biological Laboratory, RVO-TNO, Rijswijk Z.H., The Netherlands

    R. A. OOSTERBAAN, M. E. VAN ADRICHEM & J. A. COHEN

Authors
  1. LEO BENOITON
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. N. RYDON
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. A. OOSTERBAAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. E. VAN ADRICHEM
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. A. COHEN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BENOITON, L., RYDON, H., OOSTERBAAN, R. et al. Structures of Some Acetyl-serine Peptides from Acetyl-chymotrypsin. Nature 187, 596–597 (1960). https://doi.org/10.1038/187596a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/187596a0

  • Springer Nature Limited

This article is cited by

Search

Navigation