Abstract
Goldin et al. 1 and Humpreys et al. 2 have stated that reserpine treatment in mice bearing transplanted leukæmia L 1210 caused regression of neoplasm and prolonged the survival time of these animals. These observations have directed attention to other tranquillizers as possible anticarcinogenic drugs. The growth of sarcoma 37 was inhibited by chlorpromazine treatment3. However, according to Cranston4 some tranquillizers belonging to the phenothiazine group did not show any inhibitory effects on mammary adeno-carcinomas in mice.
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References
Goldin, A., Burton, R. N., and Venditti, J. M., Science, 125, 156 (1957).
Humpreys, S. R., Venditti, J. M., Mantel, N., and Goldin, A., Proc. Amer. Assoc. Cancer Res., 2, 215 (1957).
Belkin, M., and Hardy, W. G., Science, 125, 233 (1957).
Cranston, E. M., Cancer Res., 18, 897 (1958).
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CHORAZY, M. Effect of Chlorpromazine on Crocker Sarcoma and Ehrlich Ascites Carcinoma. Nature 184, 200–201 (1959). https://doi.org/10.1038/184200a0
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DOI: https://doi.org/10.1038/184200a0
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