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Evidence of Side-Chain Cleavage during the Reaction of Epinephrine and Norepinephrine with Ethylene Diamine

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Abstract

IN a previous communication1, we reported that several products are obtained from the condensation of epinephrine and norepinephrine with ethylene diamine according to the Weil-Malherbe and Bone procedure2. Recently Yagi and Nagatsu3 have suggested that the main product from norepinephrine in this reaction is identical with a secondary product of epinephrine probably by a process of demethylation of the latter.

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References

  1. Nadeau, G., and Joly, L. P., Nature, 182, 180 (1958).

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  2. Weil-Malherbe, H., and Bone, A. D., Biochem. J., 51, 311 (1952).

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  3. Yagi, K., and Nagatsu, T., Nature, 183, 822 (1959).

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Authors and Affiliations

  1. Biochemistry Department, Hospital Saint-Michel Archange, Quebec

    LOUIS-P. JOLY & GUY NADEAU

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  1. LOUIS-P. JOLY
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  2. GUY NADEAU
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JOLY, LP., NADEAU, G. Evidence of Side-Chain Cleavage during the Reaction of Epinephrine and Norepinephrine with Ethylene Diamine. Nature 184, 1483–1484 (1959). https://doi.org/10.1038/1841483a0

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  • DOI: https://doi.org/10.1038/1841483a0

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