Abstract
MITOMYCIN C, a newly isolated antibiotic, is receiving special attention because of its anti-neo-plastic activity as well as its selective inhibitory action on the synthesis of bacterial deoxyribonucleic acid.1 It has also been observed that the impaired deoxyribonucleic acid synthesis of cells of Escherichia coli B treated with mitomycin C can be promptly restored by infection with the bacteriophage T2r 2. These properties suggested that this antibiotic could induce the development of active phage from the prophage state in lysogenic bacteria, since they are similar to ultra-violet effects. This communication concerns the lytic process of Escherichia coli K–12 induced by mitomycin C added externally.
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OTSUJI, N., SEKIGUCHI, M., IIJIMA, T. et al. Induction of Phage Formation in the Lysogenic Escherichia coli K-12 by Mitomycin C . Nature 184, 1079–1080 (1959). https://doi.org/10.1038/1841079b0
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DOI: https://doi.org/10.1038/1841079b0
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