Abstract
RECURRENT inhibition via interneurones (Renshaw cells) was recently invoked by Brooks and Wilson1 to account for changes in monosynaptic spinal reflexes following antidromic activation. This mechanism, which confines stretch reflexes to their paths of afferent origin, operates through a cholinergic synapse between the motoneurone axon collateral and the Renshaw cell2, which liberates an unknown inhibitory transmitter. Presumably the same mechanism functions with respect to disynaptic pathways through the cord. The purpose of this communication is to describe an analogous system in the cerebral cortex of dogs, operated under ether and immobilized by succinylcholine.
Similar content being viewed by others
References
Brooks, V. B., and Wilson, V. J., Science, 127, 28 (1958).
Eccles, J. C., Fatt, P., and Koketsu, K., J. Physiol., 126, 524 (1954).
Phillips, C. G., Quart. J. Exp. Physiol., 41, No. 1 (1956).
Li, C. I., J. Physiol., 133, 40 (1956).
Chang, H. T., J. Neurophysiol., 18, 452 (1955).
Morrell, R. M. (unpublished observations).
Bishop, G. H., Hernry Ford Hospital Symp. Reticular Formation, 413 (1958).
Jung, R., Third Intern Congr. E.E.G., and Clin. Neurophysiol. Surp., 4, 57 (1953).
Morrell, R. M., paper presented at meeting of Eastern Association of Electroencephalographers, New York (Dec. 10, 1958).
Milner, P. M., Psychol. Rev., 64, No. 4 (July 1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MORRELL, R. Recurrent Inhibition in Cerebral Cortex. Nature 183, 979–980 (1959). https://doi.org/10.1038/183979a0
Issue Date:
DOI: https://doi.org/10.1038/183979a0
- Springer Nature Limited
This article is cited by
-
Unit responses of the sensomotor cortex to paired electrical stimuli
Neurophysiology (1974)
-
Synaptic responses of sensorimotor cortical neurons to direct cortical stimulation
Bulletin of Experimental Biology and Medicine (1970)
-
Cortical inhibitory neurons
Neuroscience Translations (1968)
-
Postsynaptic potentials in motor cortex of waking rabbit
Neuroscience Translations (1967)
-
The significance of the recurrent collateral in the structural organization of nervous centers
Bulletin of Experimental Biology and Medicine (1962)