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Purification of Neuraminidase from Vibrio cholerae

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Abstract

Blix, Gottschalk, and Klenk1 proposed the name ‘neuraminidase’ for the enzyme which splits the glycosidic linkage joining terminal (substituted or unsubstituted) neuraminic acid to residual oligo- or poly-saccharide. Kuhn and Brossmer2 and recently Gottschalk and Graham3 have isolated well-defined substrates by which the enzymatic action of neuraminidase could be studied. There exist many other substrates of high molecular weight and unknown structure; for example, mucoproteins from urine, saliva, serum, or stromata of erythrocytes. Neuraminidase is present in viruses of the myxo-group (influenza, fowl plague, Newcastle disease, mumps) and was found in filtrates of Vibrio cholerae 4 and Clostridium welchii 5.

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References

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Authors and Affiliations

  1. Max-Planck-Institut für Virusforschung, Tübingen

    GERHARD SCHRAMM & ELISABETH MOHR

Authors
  1. GERHARD SCHRAMM
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  2. ELISABETH MOHR
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SCHRAMM, G., MOHR, E. Purification of Neuraminidase from Vibrio cholerae . Nature 183, 1677–1678 (1959). https://doi.org/10.1038/1831677a0

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