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Reserpine Derivatives with Specific Hypotensive or Sedative Activity

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Abstract

RECENTLY it has been reported, by Ciba Laboratories1,2, that two reserpine analogues show more specific effects than reserpine. Methyl-18-O(3-NN-dimethylaminobenzoyl)reserpate (or SU 5171) exhibits sedative activity, while carbethoxysyringoyl-methylreserpate (syrosingopine or SU 3118) is effective in decreasing blood tension (see formulæ).

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References

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  2. Plummer, A. J., Barrett, W. E., Maxwell, R. A., Finocchio, D., Lucas, R. A., and Rutledge, E., Abstracts Fall Meeting Amer. Pharm. Soc., Arbor (Mien.), 27 (1958).

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Authors and Affiliations

  1. Institute of Pharmacology, University of Milan,

    S. GARATTINI, A. MORTARI, A. VALSECCHI & L. VALZELLI

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  1. S. GARATTINI
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  2. A. MORTARI
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  3. A. VALSECCHI
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  4. L. VALZELLI
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GARATTINI, S., MORTARI, A., VALSECCHI, A. et al. Reserpine Derivatives with Specific Hypotensive or Sedative Activity. Nature 183, 1273–1274 (1959). https://doi.org/10.1038/1831273a0

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