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Activity of 10-Hydroxydecenoic Acid from Royal Jelly against Experimental Leukæmia and Ascitic Tumours

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Abstract

DESPITE many investigations of royal jelly1, its chemistry and pharmacological activity have not been completely established. As part of a long-term study on the chemistry and biological activity of royal jelly2 we have recently investigated its possible anti-tumour properties. In this communication we wish to report that admixture of royal jelly with tumour cells before inoculation completely suppresses the development of a transplantable mouse leukæmia and the formation of ascitic tumours in mice. Fractionation studies have established that this anti-tumour activity resides in the main fatty acid of the royal jelly—10-hydroxydecenoic acid.

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Authors and Affiliations

  1. Department of Apiculture, Ontario Agricultural College, Guelph

    GORDON F. TOWNSEND

  2. Department of National Health and Welfare, Laboratory of Hygiene, Ottawa

    JOSEPH F. MORGAN

  3. Department of Therapeutics, University of Toronto, Toronto

    BARBARA HAZLETT

Authors
  1. GORDON F. TOWNSEND
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  2. JOSEPH F. MORGAN
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  3. BARBARA HAZLETT
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TOWNSEND, G., MORGAN, J. & HAZLETT, B. Activity of 10-Hydroxydecenoic Acid from Royal Jelly against Experimental Leukæmia and Ascitic Tumours. Nature 183, 1270–1271 (1959). https://doi.org/10.1038/1831270a0

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