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Ageing of Human Cartilage

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Abstract

IN a recent study of human costal cartilage, the isolation of kerato-sulphate in addition to chondroitin sulphate was reported in two cases of Marfan's syndrome and in two young adults free of skeletal abnormalities1. In earlier work on hyaline mammalian cartilage, including that of new-born infants, no keratosulphate fraction had been encountered2. Moreover, rib cartilage of the new-born yielded only chondroitin-4-sulphate (A), while in the adult the fraction was predominantly chondroitin-6-sulphate (C)3. These findings, as well as the demonstration of a shift from D-galactosamine to glucosamine with increasing age in epiphyseal human cartilage4, suggested a study of the distribution of chondroitin sulphate and keratosulphate in rib cartilage of various age-groups.

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References

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Author notes

  1. DAVID KAPLAN: U.S. Public Health Service Trainee.

Authors and Affiliations

  1. Department of Medicine, Columbia University College of Physicians and Surgeons,

    DAVID KAPLAN & KARL MEYER

  2. the Edward Daniels Faulkner Arthritis Clinic, Presbyterian Hospital, New York

    DAVID KAPLAN & KARL MEYER

Authors
  1. DAVID KAPLAN
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  2. KARL MEYER
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KAPLAN, D., MEYER, K. Ageing of Human Cartilage. Nature 183, 1267–1268 (1959). https://doi.org/10.1038/1831267a0

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