Abstract
A STUDY is being made in this Department on the metabolism of vitamin B12 in the albino rat, and on the effects of deficiency of this vitamin produced by dietary and other means. As part of this study, the possibility was investigated of using microbiological assays of vitamin B12 activity in serum to assess the nutritional state of the animals with regard to vitamin B12 in the same way as in human subjects. This communication describes preliminary results obtained on normal and gastrectomized rats and on rats which had been kept on a diet deficient in vitamin B12.
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References
Spray, G. H., Clin. Sci., 14, 661 (1955).
Spray, G. H., and Witts, L. J., Brit. Med. J., i, 295 (1958).
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SPRAY, G., TAYLOR, K. Vitamin B12 Activity in the Serum of the Rat. Nature 182, 1309–1310 (1958). https://doi.org/10.1038/1821309a0
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DOI: https://doi.org/10.1038/1821309a0
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