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Effect of Hypoglycin A on the Alpha Cells of the Pancreas

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Abstract

HYPOGLYCIN-A, which is isolated from the fruit of Blighia sapida, causes severe hypoglycæmia and depletion of liver glycogen1,2. Leppla and Holt3 examined the hypothesis that glucagon depletion following pancreatic alpha-cell damage might be the cause of these metabolic changes. However, as they could not find any microscopical changes in the alpha cells after hypoglycin A administration, they were unable to support this hypothesis.

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References

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Authors and Affiliations

  1. Division of Pharmacology, Department of Physiology, University College of the West Indies, Jamaica

    P. C. FENG

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  1. P. C. FENG
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FENG, P. Effect of Hypoglycin A on the Alpha Cells of the Pancreas. Nature 180, 855–856 (1957). https://doi.org/10.1038/180855a0

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