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A Semi-continuous Method for the Large-scale Production of Tetanus Toxin

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Abstract

THE production of large quantities of tetanus toxin for human immunization was greatly facilitated by the isolation of the highly toxigenic Harvard strain of Cl. tetani by the late Dr. J. H. Mueller and by his success in the provision of a medium suited to this strain. This preliminary report concerns the adaptation of small-scale experimental work to large-scale semi-continuous production, and since it has been possible to reproduce in large vessels the results obtained in 6 in. × 1 in. test-tubes it may be of help to others to describe the lines we have followed and the results that have been obtained.

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References

  1. Mueller, J. H., and Miller, P. A., J. Immunol., 50, 377 (1945).

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  2. Mueller, J. H., and Miller, P. A., J. Bact., 67, 271 (1954).

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Authors and Affiliations

  1. Wellcome Research Laboratories (Biological Division), Langley Court, Beckenham, Kent

    ROBERT O. THOMSON

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  1. ROBERT O. THOMSON
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THOMSON, R. A Semi-continuous Method for the Large-scale Production of Tetanus Toxin. Nature 180, 1126–1127 (1957). https://doi.org/10.1038/1801126a0

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