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The energy landscape in non-biological and biological molecules

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Abstract

The concept of energy landscapes promises to connect aspects of biology, chemistry and physics. A recent paper highlights the need for continuous exchange of information between fields to maximize the utility of this idea.

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Figure 1: A very simple and a very complex energy landscape.
Figure 2: Hierarchical tree representation of part of the energy landscape of crambin.
Figure 3: Pictorial correspondence between the potential energy surface and the tree diagram for three different energy landscapes.

References

  1. Sherrington, D. Physica D 107, 117–121 (1997).

    Article  Google Scholar 

  2. Feynman, R.P., Leighton, R.B. & Sands, M. The Feynman lectures on physics, III-8-6, III-9 (Addison-Wesley, Reading Massachusetts; 1963).

    Google Scholar 

  3. Frauenfelder, H., Sligar, S.G. & Wolynes, P.G. Science 254, 1598–1603 (1991).

    Article  CAS  Google Scholar 

  4. Frauenfelder, H. et al. eds Landscape paradigms in physics and biology – concepts, structures and dynamics. (North-Holland, Amsterdam; 1997).

    Google Scholar 

  5. Garcia, A.E., Blumenfeld, R., Hummer, G. & Krumhansl, J.A. Physica D 107, 225–239 (1997).

    Article  CAS  Google Scholar 

  6. Czerminski, R. & Elber, R.J. J. Chem. Phys. 92, 5580–5601 (1990).

    Article  CAS  Google Scholar 

  7. Becker, O.M. & Karplus, M.J. J. Chem. Phys. 106, 1495–1517 (1997).

    Article  CAS  Google Scholar 

  8. Wales, D.J., Miller, M.A. & Walsh, T.R. Nature, 394, 758–760 (1998).

    Article  CAS  Google Scholar 

  9. Ansari, A. et al. Proc. Natl. Acad. Sci. USA 82, 5000–5004 (1985).

    Article  CAS  Google Scholar 

  10. Thorn Leeson, D. and Wiersma, D.A. Nature Struct. Biol. 2, 849–852 (1995).

    Google Scholar 

  11. Frauenfelder, H. Nature Struct. Biol. 2, 821–823 (1995).

    Article  CAS  Google Scholar 

  12. Jackson, T.A., Lim, M. & Anfinrud, P.A. Chem. Phys. 180, 131–140 (1994).

    Article  CAS  Google Scholar 

  13. Thorn Leeson, D, Wiersma, D.A., Fritsch, F. & Friedrich, J. J. Chem. Phys. B 101, 6331–6340 (1997).

    Article  Google Scholar 

  14. Levinthal, C., In Mössbauer Spectroscopy in Biological Systems (eds Debrunner, P., Tsibris, J.C.M. & Münck, E.) (University of Illinois Engineering Publications, Urbana; 1969).

    Google Scholar 

  15. Onuchic, J.N., Luthey-Schulten, Z. & Wolynes, P.G. Ann. Rev. Phys. Chem. 48, 545–600 (1997).

    Article  CAS  Google Scholar 

  16. Dill, K.A. & Chan, H.S. Nature Struct. Biol. 4, 10–19 (1997).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Hans Frauenfelder.

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Frauenfelder, H., Leeson, D. The energy landscape in non-biological and biological molecules. Nat Struct Mol Biol 5, 757–759 (1998). https://doi.org/10.1038/1784

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