Abstract
MUCOPOLYSACCHARIDES are abundant in healing wounds and other sites where collagen is forming, and Meyer1 postulated their production in large quantities by fibroblasts. The mast cell has been credited with producing ‘ground substance’2 or hyaluronic acid3; but Bunting and Bunting4 recently reviewed much of the evidence for the source of mucopolysaccharide in fibroplasia and came to the conclusion that an origin from ‘fibrocytes’ seemed probable but not conclusive. Klemperer5 expressed similar views: his objections were based largely on the non-specificity of the periodic acid–Schiff method for mucopolysaccharides. Gersh and Catchpole6 had postulated previously a secretory cycle in fibroblasts dependent on the specificity of this technique.
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References
Meyer, K., Physiol. Rev., 27, 335 (1947).
Sylvén, B., Acta chir. Scand., 86, Supp. 66, 1 (1941).
Asboe-Hansen, G., Cancer Res., 13, 587 (1953).
Bunting, C. H., and Bunting, H., Arch. Path., 55, 257 (1953).
Klemperer, P., Amer. J. Path., 26, 505 (1950); Bull. New York Acad. Med., 28, 204 (1952).
Gersh, I., and Catchpole, H. R., Amer. J. Anat., 85, 457 (1949).
Curran, R. C., Brit. J. Exp. Path., 33, 82 (1952); J. Path. Bact., 66, (1), 271 (1953).
Curran, R. C., and Kennedy, J. S., J. Path. Bact. (in the press).
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CURRAN, R., KENNEDY, J. Utilization of Sulphate Ion by Fibroblasts in the Quartz Focus. Nature 175, 435–436 (1955). https://doi.org/10.1038/175435b0
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DOI: https://doi.org/10.1038/175435b0
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