Abstract
A PAPER by Zajicek and Datta1 describing the presence of a high concentration of acetylcholine esterase or ‘true’ cholinesterase in the thrombocytes of rat blood recently came to my attention. I have known for some time that considerable ‘true’ cholinesterase is to be found in the white layer of centrifuged rat blood, and while I was working at the Medical Research Laboratories of the Defence Research Board, Ottawa, Canada, I showed by substrate and inhibitor studies that this is a typical ‘true’ cholinesterase. It was my opinion at that time that the enzyme was in the leucocytes rather than in the platelets; but in all other respects my work with rat blood confirmed the findings of the above authors.
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References
Zajicek, I., and Datta, N., Acta Haematologica, 7, 39 (1952).
McCance, R. A., Hutchinson, A. O., Dean, R. F. A., and Jones, P. E. H., Biochem. J., 45, 493 (1949).
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HINES, B. Acetylcholine Esterase of the White Components of Blood. Nature 170, 78–79 (1952). https://doi.org/10.1038/170078b0
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DOI: https://doi.org/10.1038/170078b0
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