Abstract
THE mechanism of the effect of alloxan has been examined thoroughly by several investigators. For example, Abderhalden1 found that if the application of alloxan was preceded by an injection of cysteine, he was able to prevent diabetes. Brückmann and Wertheimer2 found that the level of reduced glutathione in the blood fell after an injection of alloxan. In our previous work3, we showed that alloxan reacts with SH-groups of blood proteins; this was proved polarographically. Further, we found that we could trace the fall of reduced glutathione not only in the blood but also, after a longer period of time following the injection of alloxan, in the pancreas, liver and, mainly, in the adrenals4.
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BRADA, Z. Inhibitory Effect of Tetraethylammoniumbromide in Alloxan Diabetes. Nature 169, 586–587 (1952). https://doi.org/10.1038/169586b0
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DOI: https://doi.org/10.1038/169586b0
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