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Formation of ‘Heinz Bodies’ by a Thiosemicarbazone

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Abstract

THE marked suppressive action which p-acetyl-amino-benzal-thiosemicarbazone exerts in experimental tuberculosis as first shown by Domagk1, and its effect in certain forms of human tuberculosis as reported by Mertens and Bunge2, make the study of toxic side-effects of this drug an urgent necessity. Although the occurrence of hæmolytic anæmia has been observed clinically2, no experimental anæmias produced by this drug in laboratory animals have been reported to date. The following observations may give an indication of the type of change which erythrocytes undergo during p-acetylamino-benzal-thiosemicarbazone therapy.

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References

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Authors and Affiliations

  1. Connaught Medical Research Laboratories, University of Toronto, Toronto

    C. O. SIEBENMANN & A. ZUBRYS

Authors
  1. C. O. SIEBENMANN
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  2. A. ZUBRYS
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SIEBENMANN, C., ZUBRYS, A. Formation of ‘Heinz Bodies’ by a Thiosemicarbazone. Nature 169, 505–506 (1952). https://doi.org/10.1038/169505a0

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